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January 26, 1979

Chloroquine-Resistant Falciparum Malaria From Africa

Author Affiliations

From the Tropical Medicine Unit, Division of Infectious Disease, Department of Medicine, The New York Hospital-Cornell Medical Center, New York.

JAMA. 1979;241(4):395. doi:10.1001/jama.1979.03290300037026

FALCIPARUM malaria resistant to prophylactic and therapeutic doses of chloroquine phosphate is widespread in Southeast Asia, especially in Vietnam, and occurs in South America, especially in Colombia and Brazil. This development is truly calamitous, since what was almost an ideal drug is becoming of limited value. All malariologists have dreaded the day when chloroquine-resistant malaria from Africa would be described.1 Alas, evidence presented in two case reports would indicate that the day is here.

Report of a Case  A 49-year-old zoologist who had traveled extensively throughout the world, including Africa, was in generally good health and gave no history of previous malaria. On Feb 25, 1978, he left the United States, taking a group of civilians on a tour of the Kenya highlands. He remained there 17 days and returned to New York on March 17. Two weeks before departure, he began taking chloroquine phosphate (Aralen Phosphate), prophylaxis 500