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December 12, 1986

Isoniazid Overdose in the Cambodian Population of Olmsted County, Minnesota

Author Affiliations

From the Division of Community Internal Medicine (Drs Blanchard, Yao, and Hurt) and the Department of Psychiatry and Psychology (Dr McAlpine), Mayo Clinic and Mayo Foundation, Rochester, Minn.

JAMA. 1986;256(22):3131-3133. doi:10.1001/jama.1986.03380220097030

Eight cases of suicidal isoniazid overdose by Cambodian refugees are reviewed. In all patients generalized seizures and metabolic acidosis developed. Treatment included supportive measures and intravenous pyridoxine hydrochloride. There were no deaths. Psychiatric evaluation of each patient revealed usual and extraordinary life and social adjustment stresses. Indochinese immigrants are a subpopulation at risk for isoniazid overdose.

(JAMA 1986;256:3131-3133)