Eight cases of suicidal isoniazid overdose by Cambodian refugees are reviewed. In all patients generalized seizures and metabolic acidosis developed. Treatment included supportive measures and intravenous pyridoxine hydrochloride. There were no deaths. Psychiatric evaluation of each patient revealed usual and extraordinary life and social adjustment stresses. Indochinese immigrants are a subpopulation at risk for isoniazid overdose.
Blanchard PD, Yao JDC, McAlpine DE, Hurt RD. Isoniazid Overdose in the Cambodian Population of Olmsted County, Minnesota. JAMA. 1986;256(22):3131-3133. doi:10.1001/jama.1986.03380220097030