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Article
March 16, 1979

Holoprosencephaly and Trisomy 13 in a Cyclops

Author Affiliations

Howard University College of Medicine Washington, DC

JAMA. 1979;241(11):1109. doi:10.1001/jama.1979.03290370017018
Abstract

To the Editor.—  Holoprosencephaly is the term applied to the failure of the telencephalon to divide into two hemispheres.1 The spectrum of severity of the defect ranges from the failure of the olfactory system to develop (arrhinencephaly) to failure of evagination and cleavage of the prosencephalon (cyclops).1Chromosomal analysis has been reported in some cases of cyclops, but only a few have been studied by the trypsin-Giemsa banding technique.2 We report a case of cyclopia associated with holoprosencephaly and trisomy 13 (47 XX, 13+) identified by the banding pattern analysis.

Report of a Case.—  The proposita was the outcome of the third pregnancy of a 36-year-old woman who had two other normal children. The age of the husband was not stated, but there was no evidence of a consanguineous relationship. After 34 weeks of an uncomplicated pregnancy for the mother, a live, female infant (2,750 g) with the

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