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To the Editor.—
The Food and Drug Administration is conducting hearings with the view of discontinuing certification for the production of U-80 and U-40 insulin with those products being replaced by U-100 insulin. The zeal to change insulin dosages to 100-unit metric measurements in some instances may not be clinically wise. A number of diabetic patients, particularly the elderly, are unable to make fine measurements because their hands shake and because their vision is poor. Generally it is easier for an elderly diabetic patient to make measurements with the U-40 insulin than with the U-100 insulin. Low-dose syringes are available and are a partial help for the problem.Greater attention should be paid to the difficulties of handicapped patients in making accurate measurements with insulin if the drug is to be exclusively of the U-100 dosage form.
Rabin J. Need for U-40 Insulin. JAMA. 1979;241(12):1230. doi:10.1001/jama.1979.03290380014015