Five benzodiazepine drugs (diazepam, flunitrazepam, flurazepam hydrochloride, nitrazepam, and triazolam) were evaluated separately in 15 sleep laboratory studies. Rebound insomnia, a worsening of sleep compared with baseline, occurred following withdrawal of triazolam, nitrazepam, and flunitrazepam after they had been given in only single, nightly doses for short periods. The rebound insomnia was attributed to the short and intermediate half-lives of these drugs. Diazepam and flurazepam, which have longer half-lives, did not cause rebound insomnia on withdrawal. Rebound insomnia may play a role in the development of hypnotic drug dependence with shorter-acting benzodiazepine drugs.
(JAMA 241:1692-1695, 1979)
Kales A, Scharf MB, Kales JD, Soldatos CR. Rebound InsomniaA Potential Hazard Following Withdrawal of Certain Benzodiazepines. JAMA. 1979;241(16):1692-1695. doi:10.1001/jama.1979.03290420018017