[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.197.142.219. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
February 27, 1987

Reversible Orthostatic Hypotension of Pernicious Anemia

Author Affiliations

From the Department of Medicine, University of New Mexico, and the Veterans Administration Medical Center, Albuquerque.

From the Department of Medicine, University of New Mexico, and the Veterans Administration Medical Center, Albuquerque.

JAMA. 1987;257(8):1084-1086. doi:10.1001/jama.1987.03390080074035
Abstract

IN 1980, White et al1 published a case report that suggested that pernicious anemia could induce a reversible state of orthostatic hypotension, in the absence of other neuropathic signs. This index case was embraced as proved, and incorporated into texts and medical references,2 despite the following limitations: (1) the observation was never confirmed by other observers, (2) the period of follow-up was only two months and did not preclude the possibility of relapse or fluctuation of signs and symptoms, and (3) the case history included findings that some argue reflect the presence, albeit subtle, of concomitant peripheral neuropathy.

In the same year a patient was seen in our facility with orthostatic hypertension. The clinical course of this patient confirms the relationship proposed by White et al and strengthens their observation by demonstrating reproducibility of the phenomenon and the subsequent persistence of remission after appropriate therapy for 24 months.

×