To the Editor.—
I cannot agree with the statement by Amrein et al (1981; 245:1825) that an average additional blood loss of 400 mL "is not of great clinical importance." Interestingly, we noted a similar degree of excessive blood loss attributable to aspirin use in patients undergoing coronary artery bypass graft surgery.1 We also saw excessive bleeding in patients with normal bleeding times, including some patients who had ingested only 600 mg of aspirin in the week before surgery.
Michelson EL. Aspirin and Perioperative Blood Loss. JAMA. 1981;246(24):2808. doi:10.1001/jama.1981.03320240018013