We examined digoxin-prescribing in 47,000 prescriptions written predominantly by physicians in a large family medicine practice. Two hundred fifty-four patients received 511 digoxin prescriptions. Dose adjustments for age (16% decrease in patients older than 64 years), for renal disease (33% decrease), and for atrial fibrillation (39% increase) followed good prescribing practices. Appropriately lower loading doses were used for digitalization. However, despite continuing concern over the bioavailability of generic digoxin tablets, less than 40% of digoxin prescriptions in this study were written for the innovator's brand-name product (Lanoxin).
(JAMA 242:445-448, 1979)
Weintraub M, Karch FE, Morgan JP, Trabert N, Sorensen A, Becker LA, Lasagna L. Digoxin-PrescribingMostly Good News. JAMA. 1979;242(5):445-448. doi:10.1001/jama.1979.03300050035023