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This monograph deals exclusively with various types of vasculitis, disorders arising from normal host-defense mechanisms, a response that not infrequently goes amiss. The conditions falling into such a category consist of a confusing and puzzling but still interesting group of syndromes with overlapping pathological changes. They have in common circulating immune complexes that are capable of adhering to vessel walls and reducing lumen size. The material in the 15 chapters is based on a study of patients at the National Institutes of Health over a period of 15 years, together with an extensive survey of the pertinent literature. Each entity is discussed from the standpoint of pathogenesis, immunology, pathology, clinical manifestations, and therapeutics, the approach being suitable for the needs and interests of the internist.
Following three introductory chapters on classification, pathophysiology, and laboratory studies of the vasculitides, the most common group of entities, the systemic necrotizing vasculitis of the
Abramson DI. The Vasculitides. JAMA. 1982;247(2):237–238. doi:10.1001/jama.1982.03320270061031