Twenty-four percent (7/29) of human immunodeficiency virus—infected women seen at Walter Reed Army Medical Center between 1983 and 1986 presented with a history of chronic refractory vaginal candidiasis. In addition to vaginal candidiasis, all patients were found to have oral thrush on physical examination, severe T-helper cell depletion (mean T-helper cell count of 90), and markedly decreased T4/T8 ratios (mean, 0.3); six of seven women were anergic by delayed-type hypersensitivity skin testing. The conditions of six (86%) of these seven women have progressed to acquired immunodeficiency syndrome (WR6 classification). Chronic refractory vaginal candidiasis may be a presenting symptom of human immunodeficiency virus infection. Women with human immunodeficiency virus infection and unexplained oral and vaginal candidiasis are at high risk to develop other opportunistic infections.
Rhoads JL, Wright DC, Redfield RR, Burke DS. Chronic Vaginal Candidiasis in Women With Human Immunodeficiency Virus Infection. JAMA. 1987;257(22):3105-3107. doi:10.1001/jama.1987.03390220103029