Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.
(JAMA 242:1896-1898, 1979)
Husserl FE, Lange RK, Kantrow CM. Renal Papillary Necrosis and Pyelonephritis Accompanying Fenoprofen Therapy. JAMA. 1979;242(17):1896–1898. doi:10.1001/jama.1979.03300170042027