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October 26, 1979

Renal Papillary Necrosis and Pyelonephritis Accompanying Fenoprofen Therapy

Author Affiliations

From the Department of Medicine, Section on Hypertension and Renal Disease (Drs Husserl and Kantrow) and Rheumatology (Dr Lange), Ochsner Medical Institutions, New Orleans.

JAMA. 1979;242(17):1896-1898. doi:10.1001/jama.1979.03300170042027

Renal papillary necrosis occurred after fenoprofen calcium administration in a patient with systemic lupus erythematosus and urinary tract infection. Possible mechanisms of renal damage may be hypersensitivity, decreased blood flow, and decreased production of a prostaglandin E-like substance.

(JAMA 242:1896-1898, 1979)