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July 17, 1987

Blood Pressure and Calcium Supplementation-Reply

Author Affiliations

Purdue University West Lafayette, Ind

Purdue University West Lafayette, Ind

JAMA. 1987;258(3):326-327. doi:10.1001/jama.1987.03400030042026

In Reply.—  The comments and questions of Drs Cappuccio and Strazzullo are appreciated. We, too, believe that rigorously designed and carefully presented studies are needed to answer basic questions about the relationship between oral calcium intake and blood pressure. Our choice of a normotensive population was justified by our interest in nonpharmacologic approaches to the primary prevention of hypertension as well as the treatment of established hypertension. The entire range of the blood pressure distribution should be examined with respect to proposed interventions to determine their potential for prevention and treatment of hypertension. Only two previously reported studies1,2 have examined the impact of increased calcium intake in normotensives and none have specifically addressed the possibility of racial differences in blood pressure response to calcium supplementation.It is a matter of opinion whether covariance is appropriate when a randomized design is employed and baseline values are not significantly different between