We used charcoal hemoperfusion coupled with hemodialysis to treat a woman with massive digoxin ingestion complicated by hyperkalemia. Although dialysis controlled the serum potassium levels, hemoperfusion removed less than 1% of the total ingested dose. Hemoperfusion has a relatively minor impact on digoxin elimination and remains of unproved value in the therapy for digoxin overdose.
(JAMA 242:2100-2101, 1979)
Warren SE, Fanestil DD. Digoxin Overdose Limitations of Hemoperfusion-Hemodialysis Treatment. JAMA. 1979;242(19):2100–2101. doi:10.1001/jama.1979.03300190040024