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November 16, 1979

High-Density Lipoprotein-Cholesterol in Survivors of Myocardial Infarction

Author Affiliations

From the Department of Medicine, University of Washington School of Medicine, and the Northwest Lipid Research Clinic, Seattle. Dr Erkelens is now with the Kliniek voor Inwendige Ziekten, Academish Ziekenhuis, Utrecht, Netherlands.

JAMA. 1979;242(20):2185-2189. doi:10.1001/jama.1979.03300200015014

High-density lipoprotein-cholesterol (HDL-Chol) levels were higher in a group of 83 myocardial infarction survivors who participated in a moderate, graded exercise program (47±13 mg/dL) than in 103 nonexercising coronary heart disease patients (40±11 mg/dL, P<.001), reaching levels undistinguishable from those of 181 population controls (44±12 mg/dL). The level of exercise and concentration of HDL-Chol were correlated (r =.24, P<.05). In 18 patients studied longitudinally, HDL-Chol levels increased from 35±8 mg/dL before participation to 40 mg/dL (P<.001) after one week, and remained at that level for six months. Concurrently, functional aerobic impairment decreased from 31%±29% to 11% (P<.01). These observations suggest that participation in a moderate exercise program increases HDLChol levels in myocardial infarction survivors and may contribute to lowering the risk for subsequent infarction.

(JAMA 242:2185-2189, 1979)