High-density lipoprotein-cholesterol (HDL-Chol) levels were higher in a group of 83 myocardial infarction survivors who participated in a moderate, graded exercise program (47±13 mg/dL) than in 103 nonexercising coronary heart disease patients (40±11 mg/dL, P<.001), reaching levels undistinguishable from those of 181 population controls (44±12 mg/dL). The level of exercise and concentration of HDL-Chol were correlated (r =.24, P<.05). In 18 patients studied longitudinally, HDL-Chol levels increased from 35±8 mg/dL before participation to 40 mg/dL (P<.001) after one week, and remained at that level for six months. Concurrently, functional aerobic impairment decreased from 31%±29% to 11% (P<.01). These observations suggest that participation in a moderate exercise program increases HDLChol levels in myocardial infarction survivors and may contribute to lowering the risk for subsequent infarction.
(JAMA 242:2185-2189, 1979)
Erkelens DW, Albers JJ, Hazzard WR, Frederick RC, Bierman EL. High-Density Lipoprotein-Cholesterol in Survivors of Myocardial Infarction. JAMA. 1979;242(20):2185–2189. doi:10.1001/jama.1979.03300200015014