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November 30, 1979

CSF Eosinophilia Following Myelography

Author Affiliations

From the Division of Infectious Diseases, Baltimore Veterans Administration Hospital; and the University of Maryland School of Medicine, Baltimore. Dr Holley is now with the Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston.

JAMA. 1979;242(22):2432-2433. doi:10.1001/jama.1979.03300220044024

WE recently encountered a patient in whom eosinophilic meningitis developed following myelography with iophendylate (Pantopaque). This unusual reaction has been described previously in only two patients1 and, to our knowledge, never in the English language literature.

Report of a Case  A 56-year-old man was admitted to the Baltimore Veterans Administration Hospital with a history of increasing weakness on the left side and neck pain exacerbated by motion over the previous six weeks. The patient had a long history of left otitis media and alcohol abuse; he had also noted a recent decrease in the force of micturition. Abnormal findings on physical examination were a perforated left tympanic membrane and a moderately enlarged prostate. Neurological examination demonstrated diminished hearing on the left, which was confirmed by audiometry. There were hypesthesia, hypalgesia, and a deficit of vibratory sensation involving the entire left leg to the groin. Weakness and decreased deep tendon