—Nonresponse to hepatitis B vaccine in the perinatal period occasionally occurs. This report documents the results of reimmunization of nonresponders to perinatal immunization.
—From a cohort of 1154 infants immunized with plasma-based vaccine in the perinatal period and followed up for more than 8 years, 45 nonresponders were identified. These children were reimmunized at 4 years of age. Each child received a yeast-derived recombinant hepatitis B vaccine on a 0-, 1-, and 5-month schedule, 33 children with 10-μg and 12 with 5-μg doses. Blood was sampled 1 month after the third vaccination and thereafter at 1, 2, and 4 years.
—The follow-up clinic where the cohort of children was regularly seen.
—Forty-five 4-year-old children who had no antibody to hepatitis B despite perinatal immunization.
Main Outcome Measure.
—Antibody levels to hepatitis B surface antigen.
—Seroconversion with titers higher than 10 mlU/mL occurred in all children. More than 70% still had titers higher than 10 mlU/mL 4 years after vaccination.
—Nonresponders to perinatal hepatitis B vaccination respond well to subsequent vaccination.(JAMA. 1994;271:859-861)
Tan KL, Goh KT, Oon CJ, Chan SH. Immunogenicity of Recombinant Yeast-Derived Hepatitis B Vaccine in Nonresponders to Perinatal Immunization. JAMA. 1994;271(11):859-861. doi:10.1001/jama.1994.03510350069039