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October 2, 1987

Intravenous Labetalol in Acute Aortic Dissection

Author Affiliations

Albany (NY) Medical College

Albany (NY) Medical College

JAMA. 1987;258(13):1732. doi:10.1001/jama.1987.03400130046022

To the Editor.—  In their CASE REPORT on labetalol hydrochloride therapy for acute aortic dissection, Grubb et al1 used a 20-mg bolus followed by a continuous infusion of 2 mg/min for two days. The total intravenous dose was therefore 5.78 g in 48 hours. The manufacturer suggests a maximum dose of 300 mg/d.2 Could the authors please comment on the dosing discrepancy?