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February 1, 1980

A Sudden Decline in Ampicillin Resistance in Salmonella typhimurium

Author Affiliations

From the Microbiology Laboratories of Brooklyn Jewish Hospital (Dr Cherubin) and Kings County Hospital (Dr Sierra), Brooklyn, NY; St Vincent's Hospital, New York (Dr Ma); New York State College of Veterinary Medicine, Cornell University, Ithaca, NY (Drs Timoney and Shin); and the Bureau of Preventable Diseases, New York City Department of Health (Dr Marr).

JAMA. 1980;243(5):439-442. doi:10.1001/jama.1980.03300310027017

Starting in 1975, an abrupt decline in ampicillin resistance of Salmonella typhimurium (the most common and antibiotic-resistant serotype) occurred in New York City. The present lower rate of 5% to 7.9% at our hospitals represents a return to the 1965 level. At the same time, the ampicillin resistance in S typhimurium from calves and other farm animals from upper New York State, which has been rising since 1972, has reached 75%. Substantial differences between levels of resistance in Escherichia coli from animals and humans were also noted. The divergence of the trends in S typhimurium from these two sources in New York State suggests a substantial degree of separation of the respective reservoirs of Salmonella and of antibiotic resistance.

(JAMA 242:439-442, 1980)