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February 15, 1980

Growth Hormone

Author Affiliations

College of Dentistry University of Illinois at the Medical Center Chicago

JAMA. 1980;243(7):652. doi:10.1001/jama.1980.03300330016017

To the Editor.—  The news of growth hormone synthesis by two laboratories on the west side of San Francisco Bay (242:701, 1979) should surely prompt a flashback to events that took place on the east side of the bay some 60 years ago. Here, at the University of California (as it was then) in 1921, Herbert M. Evans, MD, and Joseph A. Long, PhD, were the first to prepare an extract "by the simple means of trituration of the anterior lobes of the bovine (pituitary) gland with sand, the addition of Locke's solution, and centrifugation. The opaque pink fluid was injected intraperitoneally into rats."1 Results in less than three months led the investigators to announce that "an outspoken acceleration of growth had been induced."Evans and Miriam E. Simpson, MD, then began a systematic effort to find methods for the extraction and purification of the hormone. Evans died in