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February 22, 1980

Acute Renal Failure Associated With Ticrynafen

Author Affiliations

From the Departments of Medicine (Dr Paddack) and Pathology (Dr Wahl), Presbyterian-St Luke's Medical Center, Denver. Drs Holman, Schorr, and Lacher are in private practice in Denver.

JAMA. 1980;243(8):764-765. doi:10.1001/jama.1980.03300340040017

Three patients experienced acute renal failure temporally related to the use of ticrynafen. There was no clinical evidence of hypersensitivity. In all three patients, the serum uric acid level fell as they became more azotemic. It is postulated, but not proved, that acute tubular obstruction with urates may be responsible.

(JAMA 243:764-765, 1980)