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March 5, 1982

Trolamine Salicylate Cream in Osteoarthritis of the Knee

Author Affiliations

From the Department of Pharmacy Practice, College of Pharmacy (Drs Algozzine and Araujo and Mr Doering), and the Department of Medicine, Division of Clinical Immunology, College of Medicine and Center for Ambulatory Studies (Dr Stein), University of Florida, the Veterans Administration Medical Center (Dr Stein), and the Corporation for Public Medicine (Drs Algozzine and Stein), Gainesville, Fla; and Adria Laboratories, Columbus, Ohio (Mr Akin). Dr Algozzine is now with L. W. Blake Memorial Hospital, Bradenton, Fla.

JAMA. 1982;247(9):1311-1313. doi:10.1001/jama.1982.03320340065038

Twenty-five patients with symptomatic osteoarthritis (OA) of the knee were treated topically for one week with either 10% trolamine salicylate cream or placebo cream in a randomized double-blind crossover study. No significant difference was found in subjective or objective measures of pain relief between the treatment and control groups. Eight patients preferred "active" test cream, six preferred placebo, and 11 had no preference. No side effects were reported. Topically applied 10% trolamine salicylate cream did not relieve the pain of OA of the knee any more than did placebo.

(JAMA 1982;247:1311-1313)