[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.163.92.62. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Article
March 21, 1980

Herpes viruses induce atherosclerosis in chickens

JAMA. 1980;243(11):1128-1130. doi:10.1001/jama.1980.03300370008002

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

Domestic birds who have not run afoul of the Colonel may face an even harder fate at the hands of New York Hospital-Cornell University Medical Center investigators. Determined to learn more about human coronary disease by studying fowl, these researchers have recently induced atheromatous plaque formation in specific-pathogen-free White Leghorns by inoculating them intratracheally with Marek's disease herpes virus (MDV).

C. Richard Minick, MD, professor of pathology at Cornell, discussed the group's findings (Am J Pathol 96:673-706, 1979) at the recent American Heart Association science writers' forum at St Petersburg Beach, Fla.

Minick and associates divided more than 100 male chicks with normal cholesterol levels into four groups. Two of the groups were inoculated with MDV two days after birth; two were not. All groups were fed a low-cholesterol diet for 15 weeks. For 15 additional weeks, one infected group and one uninfected group received a 2% cholesterol supplement to

×