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We thank Drs Massey and Riley for their observations, particularly for their suggestion that tricyclic antidepressant drugs may alter pain in part by affecting peripheral nerve transmission. A controlled study of the effects of tricyclic antidepressants on pain, such as the one they are proposing, would be helpful, indeed.
Shimm DS, Logue GL. Tricyclic Antidepressants for Peripheral Neuropathy-Reply. JAMA. 1980;243(11):1133. doi:10.1001/jama.1980.03300370013011