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Article
November 13, 1987

A Formula for Calculating the Dosages of Drugs in Emergencies-Reply

Author Affiliations

National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Md

National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Md

JAMA. 1987;258(18):2528-2529. doi:10.1001/jama.1987.03400180062020
Abstract

In Reply.—  Dr Chen is correct to point out that "minute" need not appear in the final two versions of the universal drip formula. The formula and its use do not change, however, and a practitioner need only choose the dosage rate of the drug (in micrograms per kilogram per minute), roughly estimate the patient's weight (in kilograms), and multiply by a constant (0.5) to derive the milligrams of drug needed for a standard volume (250 mL) and drip rate (30 mL/h).The recommendation by Dr Chen to start an intravenous infusion with a drip rate of 3 or 6 mL/h and to increase the rate every ten minutes to avoid volume overload in infants raises precisely the same concerns addressed previously about slow drip rates.1 If Dr Chen's recommendations are followed, then an inordinately long time (more than 30 minutes) would elapse before intermediate and efficacious dosage rates

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