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April 13, 1994

Lipoprotein(a) and Risk of Myocardial Infarction-Reply

Author Affiliations

Brigham and Women's Hospital Boston, Mass

JAMA. 1994;271(14):1078. doi:10.1001/jama.1994.03510380033021

In Reply.  —Dr Gaw appropriately points out that racial breakdown and age are important issues to be considered when interpreting our article.With regard to race or ethnic origin, we have no direct evidence from the Physicians' Health Study. However, in a pilot study performed for this prospective trial, which included a random sampling of male physicians aged 40 to 84 years in 1982, greater than 99% of respondents were white. As discussed in our article and reiterated by Gaw, racial differences have been reported in the distribution of Lp(a). Thus, further prospective studies of adequate sample size will be required to confirm or refute our findings for other populations.Cases and controls in our study were matched within 1 year for age, making it implausible that this variable confounded our results. It is important to point out, however, that the average age at time of first MI in our

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