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April 13, 1994

Lipoprotein(a) and Risk of Myocardial Infarction-Reply

Author Affiliations

University of Pennsylvania School of Medicine Philadelphia

JAMA. 1994;271(14):1078. doi:10.1001/jama.1994.03510380033022

In Reply.  —Although it would have been helpful to know the age range of the nested study group, the age range of the population it was drawn from was reported (40 to 84 years), indicating that conclusions drawn should not apply to those less than 40 years of age. The lack of data on men less than 40 years of age prompted me to restrict my comments to men older than 40 years when I suggested that we not use routine screening of Lp(a) levels in this type of population (ie, white American men older than 40 years). I did not make any recommendation with regard to healthy men (or women) less than 40 years of age because of the lack of large, well-designed prospective studies in these population groups. In the study by Ridker et al,1 analyses stratified by age did not reveal a significant predictive utility of

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