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April 13, 1994

Depression and Survival Following Myocardial Infarction-Reply

Author Affiliations

Montreal Heart Institute Montreal, Quebec

JAMA. 1994;271(14):1081-1082. doi:10.1001/jama.1994.03510380036031

In Reply.  —We acknowledge that an error was made in calculating CIs for our article. (A Correction with corrected tables appears at the end of the Letters section.) This correction does not change the HRs originally reported. The data still support the conclusion that major depression in hospitalized patients following MI is associated with a significant increase in risk of mortality.In reply to Drs Wei and Hornung and Dr Thompson, as discussed in the original article, with a modest sample size such as ours, the number of variables that can be controlled for is limited. We believe that with our sample the best approach is adjustment for those variables that are at the same time imbalanced between the depressed and nondepressed groups and predictive of outcome,1 ie, the prescription of warfarin sodium. Control for warfarin resulted in an adjusted HR ratio of 4.81 (95% CI, 1.49 to 15.53;

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