May 9, 1980

Registry of Fatal Infectious Mononucleosis and Epstein-Barr Virus Infections

Author Affiliations

University of Massachusetts Medical Center Worcester

JAMA. 1980;243(18):1806. doi:10.1001/jama.1980.03300440012007

To the Editor.—  We have established a registry of fatal infectious mononucleosis (IM) and Epstein-Barr virus (EBV) infections that provides consultation to physicians attending patients with life-threatening IM. Enlistment of patients in this registry provides an opportunity to study the pathogenesis of complications of IM and provides bases for developing rational therapeutic intervention.Fatal and life-threatening lymphoproliferative disorders caused by EBV infection often arise from obstruction of airways or are caused by autoimmune suppression of blood elements producing hemolytic anemia, thrombocytopenia, agranulocytosis, or aplastic anemia. Acquired agammaglobulinemia and immune complex deposit diseases are rarely noted. Often in IM, infiltration of lymphocytes causes dysfunction of visceral organs and the CNS. Rarely, neoplastic conversion of IM to malignant lymphoma is seen in patients who are immunodeficient.Requirements for enrolling cases in this registry include sending to us clinical, laboratory, and autopsy records along with blood and tissue microscopic slides and paraffin-embedded tissues