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March 19, 1982

Prematurity and Perinatal Mortality in Pregnancies Complicated by Maternal Chlamydia trachomatis Infections

Author Affiliations

From the Departments of Medicine and Obstetrics and Gynecology, University of Washington School of Medicine (Drs Martin, Eschenbach, Benedetti, and Holmes), the Department of Epidemiology, University of Washington School of Public Health and Community Medicine (Ms Koutsky and Drs Daling and Alexander), and the Public Health Service Hospital (Drs Martin and Holmes), Seattle. Dr Martin is now with the Department of Medicine, Louisiana State University School of Medicine, New Orleans. Dr Alexander is now with the Department of Pediatrics, University of Arizona, Tucson.

JAMA. 1982;247(11):1585-1588. doi:10.1001/jama.1982.03320360035027

In a prospective study of morbidity associated with Chlamydia trachomatis infections during pregnancy, we isolated C trachomatis from the endocervix of 18 (6.7%) of 268 women examined before 19 weeks' gestation. Infected women were significantly younger than noninfected women, and significantly more often unmarried, supported by public assistance, and pregnant for the first time. Among women followed up from 19 weeks' gestation until delivery, the mean duration of gestation was significantly shorter for those with antepartum chlamydial infection. Stillbirth or neonatal death occurred in six (33%) of the 18 pregnancies of infected women compared with eight (3.4%) of the 238 pregnancies of noninfected women followed up from the 19th week of gestation through delivery. Stillbirth or neonatal death occurred ten times more often among Chlamydiainfected women than among uninfected controls matched for age, marital status, socioeconomic status, pregnancy order, and race.

(JAMA 1982;247:1585-1588)