Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
June 20, 1980

Carcinoma at the Site of Herpes Simplex Infection

Author Affiliations

Portland, Ore

JAMA. 1980;243(23):2396. doi:10.1001/jama.1980.03300490014007

To the Editor.—  A squamous cell carcinoma of the lip developed in a 55-year-old man at the site of a localized herpes simplex infection that had been recurrent for the previous 20 years. During this time grouped blisters occurred on the lower lip, resolving after a few weeks at intervals of a few months up to two years. In 1973, findings from a smear examination (done elsewhere) of the base of one of the blisters yielded a diagnosis of a virus infection presumably from the presence of multinucleate balloon epithelial cells. For the last two years a lesion had been present all the time. He recently had extensive induration 2 cm in thickness involving almost the entire length of the lower lip with superficial erosions and crusting. There were no enlarged regional lymph nodes. A punch biopsy specimen (by a consultant, Jon Hanifin, MD) uncovered a squamous cell carcinoma. Radiotherapy