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— Dr Cooner's comments about the improved capabilities in ultrasonic prostate imaging are well taken. I agree that biplane imaging and higher-frequency transducers have enhanced the versatility of this diagnostic modality in recent years. Unfortunately, I am still not aware of any clinical studies that convincingly support prostatic ultrasound as a dependable diagnostic screen for early prostatic cancer. For this reason, I stand behind my statement that the modality "appears to be of little use in the diagnosis of early prostatic cancer."
Palmer JM. Ultrasound in Prostatic Cancer-Reply. JAMA. 1988;259(7):1015. doi:10.1001/jama.1988.03720070021020