April 9, 1982

Correlates of Homosexual Behavior and the Incidence of Anal Cancer

Author Affiliations

From the Program in Epidemiology and Biostatistics, Fred Hutchinson Cancer Research Center (Drs Daling and Weiss), and the Department of Epidemiology, the University of Washington (Drs Daling and Weiss, Ms Chow and Mr Daifuku), Seattle; and the Washington State Department of Social and Health Services, Health Services Division, Venereal Disease Program, Olympia, Wash (Mr Klopfenstein and Ms Cochran).

JAMA. 1982;247(14):1988-1990. doi:10.1001/jama.1982.03320390050042

To determine whether characteristics that are correlated with male homosexual behavior are associated with the incidence of cancer, the names of persons with a diagnosis of cancer in western Washington during 1974 to 1979 were linked to those in the state syphilis registry. Eight of 47 men with anal cancer were found to have had a reactive FTA test result; the expected number, based on the proportion of reactive cases among men with other sites of cancer, was only 0.40. Among men with anal cancer identified through ten population-based cancer-reporting systems in the United States, 24.4% had never been married, compared with 7.8% of men with colon and rectal cancer. Neither of these relationships was observed for women with anal cancer. Because in men, but not in women, having had syphilis and being single are associated with the practice of anal intercourse, our data suggest that anal intercourse may be a risk factor for anal cancer.

(JAMA 1982;247:1988-1990)