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May 4, 1994

Immunoaugmentative Therapy

Author Affiliations

New York, NY

JAMA. 1994;271(17):1319-1320. doi:10.1001/jama.1994.03510410031022

To the Editor.  —In a critique of IAT, Dr Green1 asserts that the "normal immune system does not recognize and destroy cancer cells...." As a medical writer, I am amazed by Green's conclusion and his total dismissal of IAT serum fractions. Spontaneous remissions do occur, and some serum factors are reported to have antitumor effects.2,3In fact, Green participated in research on a "serum factor that causes necrosis of tumors."2 Dr R. L. Kassel, his coauthor in the 1975 discovery paper on tumor necrosis factor,2 was also the coauthor with Dr Burton of animal studies on IAT. Green cites these studies (references 9 and 10) but omits the antitumor results. He misrepresents Burton's 1965 report (reference 16) as one on "mouse tumor cells."Green cites no instance of contamination of IAT materials since 1986 when the IAT clinic reopened with more stringent quality control. The prior

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