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August 15, 1980

Total Parenteral Nutrition in Leukopenic Cancer Patients

Author Affiliations

From the Department of Oncology, Wayne State University, School of Medicine (Drs Dindogru and Vaitkevicius), and the Department of Pharmacy, Harper-Grace Hospital (Ms Pasick and Mr Rutkowski and Vinson), Detroit.

JAMA. 1980;244(7):680-681. doi:10.1001/jama.1980.03310070030023

Over 12 months, 26 malnourished patients had 30 episodes of leukopenia while receiving total parenteral nutrition (TPN). There were 22 episodes of leukopenia associated with high temperatures (>37.8 °C) A TPN-induced septicemia was the cause of fever in one patient. One patient with slight transient fever received no antibiotics, and 21 febrile patients were treated with various broad-spectrum antibiotics. The average duration of leukopenia was 6.9 days, and the average nadir of leukopenia was 789/cu mm. Eleven patients died during or within two weeks of the neutropenic episode. No deaths were related to TPN-induced septicemia. With proper care, TPN can be given to neutropenic patients without additional risk of sepsis.

(JAMA 244:680-681, 1980)