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—We thank Dr Dale for her interest in our recent article. She is of course entirely correct in noticing that cardiac index was significantly different between the two groups, while the other variables used to calculate the Do2I were not. We set out to test the hypothesis that increasing Do2I would reduce mortality in the patient group studied, as is clearly stated in the original article and as many others had suggested. Therefore, to suggest that in concentrating on Do2I we had a preconception about our results is incorrect. Increasing Do2I was the hypothesis to be tested and, therefore, must appear as a major part of the results, which are quoted in detailed enough form to allow readers to interpret them as they see fit. We reject the implication that we have interpreted our results to support a preconceived idea.
Boyd O, Grounds RM, Bennett ED. Increasing Oxygen Delivery in Surgical Patients-Reply. JAMA. 1994;271(17):1321. doi:10.1001/jama.1994.03510410033027