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August 22, 1980

Valproic Acid Therapy in Childhood Epilepsy

Author Affiliations

From the Department of Neurology and Section of Pediatric Neurology, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor.

JAMA. 1980;244(8):785-788. doi:10.1001/jama.1980.03310080019016

Valproic acid, used alone or in combination with other anticonvulsants in 100 children with epilepsy, improved seizure control in all age groups. Mean improvement in seizure control was 82%. Petit mal seizures responded best, but other types of seizures, even with associated mental and physical handicaps, also responded well. A substantial improvement in alertness and behavior often occurred. Leukopenia (27%) and an elevated SGOT value (44%) were frequent but transient. Other side effects included alopecia (1), gastrointestinal distress with vomiting (7), pancreatitis (1), thrombocytopenia (1), edema (2), and coma (2). Three severely retarded children with frequent seizures died while receiving valproic acid, but it is not clear that death was caused by valproic acid. Children must be monitored carefully for potential toxic effects, and drug interactions with other anticonvulsants may cause problems in treatment.

(JAMA 244:785-788, 1980)