Of 674 patients with calcium nephrolithiasis, 78 formed their stones in large numbers (average, 22 stones per patient) and at an accelerated rate (average, 172 stones per 100 patient-years). Although their stone disease was unusually severe, these patients had the common metabolic causes of stones and responded well to treatment. Patients with even the most extremely active calcium nephrolithiasis should be evaluated and managed in the same way as those with the common, less active form of the disease.
(JAMA 244:809-810, 1980)
Coe FL, Parks JH, Strauss AL. Accelerated Calcium Nephrolithiasis. JAMA. 1980;244(8):809-810. doi:10.1001/jama.1980.03310080043025