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October 3, 1980

Bolus Corticosteroids and Cyclophosphamide for Initial Treatment of Wegener's Granulomatosis

Author Affiliations

From the Departments of Pediatrics (Drs Harrison, Linshaw, and Lindsley) and Pathology and Oncology (Dr Cuppage), University of Kansas Medical Center, Kansas City. Dr Harrison is now with University School of Medicine, Norton's Children's Hospital, Louisville.

JAMA. 1980;244(14):1599-1600. doi:10.1001/jama.1980.03310140057032

Wegener's granulomatosis, a necrotizing vasculitis involving primarily the upper and lower respiratory tract and the kidney, may be rapidly fatal. We describe two children with Wegener's granulomatosis in whom we observed dramatic improvement within 72 hours following bolus corticosteroid therapy combined with cyclophosphamide.

(JAMA 244:1599-1600, 1980)