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May 11, 1994

The cancer revolution— from 'black box' to 'genetic disease'

JAMA. 1994;271(18):1452-1454. doi:10.1001/jama.1994.03510420086041

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Bert Vogelstein, MD, arrives at his office at Baltimore's Johns Hopkins Oncology Center at 5:30 in the morning—6 or 7 days a week—and he often finds one of his laboratory researchers already at work. With time out only for a lunch of bagels, toasted in the room next door, he usually stays at work until 7:30 at night. It adds up to 85 to 90 hours a week. His wife got used to it long ago. He, too, shrugs it off.

"There's a lot to do," Vogelstein told this reporter last month. "Sure, I work hard, but so does everyone in my lab. Molecular genetics requires a lot of hands-on work and most lab investigators work long and hard."

The 44-year-old Vogelstein and his team of 12 to 16 young scientists (co-supervised by Kenneth W. Kinzler) are

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