Low-dose oral methotrexate therapy was associated with the onset of anemia, leukopenia, and thrombocytopenia in two patients with psoriasis. Both patients survived, but required prolonged hospitalization. No precipitating factor other than methotrexate could be identified.
Shupack JL, Webster GF. Pancytopenia Following Low-Dose Oral Methotrexate Therapy for Psoriasis. JAMA. 1988;259(24):3594-3596. doi:10.1001/jama.1988.03720240056034