January 2, 1981

Isolated CNS Sarcoidosis

Author Affiliations

From the Department of Medicine, Baltimore City Hospitals and The Johns Hopkins University School of Medicine, Baltimore.

JAMA. 1981;245(1):62-63. doi:10.1001/jama.1981.03310260040026

ENDOCRINE hypofunction resulting from hypophysial or hypothalamic sarcoidosis is well recognized.1 Almost always, this central involvement occurs in a patient with widespread disease involving the lungs, skin, or liver. This article reports the case of a man with secondary hypogonadism attributable to sarcoidosis that apparently was confined to the CNS.

Report of a Case  A 52-year-old white man had a history of complete impotence and decreased libido of several months' duration. He denied a change in beard growth or development of breast enlargement, tenderness, or discharge. Except for easy fatigability and occasional blurred vision of recent onset, the review of systems was normal. He was taking no medications, and both past medical and family history were noncontributory.Physical examination was unremarkable except for exogenous obesity. The patiént's weight was 120 kg; height, 186 cm; and blood pressure, 136/88 mm Hg. An ophthalmologist, however, found a minimal refractive error bilaterally