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May 28, 1982

Kartagener's Syndrome

Author Affiliations

From the Department of Diagnostic Radiology (Drs Woodring and Royer) and the Department of Internal Medicine, Division of Pulmonary Medicine (Dr McDonagh), University of Kentucky Medical Center, Lexington.

JAMA. 1982;247(20):2814-2816. doi:10.1001/jama.1982.03320450048034

Kartagener's syndrome, characterized by situs inversus, paranasal sinusitis, and bronchiectasis, is part of a more generalized syndrome characterized by sterility in men, chronic bronchitis or bronchiectasis, chronic sinusitis, and chronic otitis media; it is referred to as the immotilecilia syndrome. Those patients with situs inversus will give a typical radiological appearance allowing an early diagnosis; however, in those patients with immotile-cilia syndrome who have normal visceral situs, a high index of suspicion and early electron microscopic examination of respiratory tract cilia will be necessary for early diagnosis and therapy to prevent irreversible bronchiectasis and lung destruction. We describe a young woman with bronchiectasis associated with situs inversus and chronic sinusitis, found to have abnormal respiratory epithelium cilia.

(JAMA 1982;247:2814-2816)