A 62-year-old woman with a history of acromegaly and an episode of pituitary apoplexy 18 years previously with subsequent biochemical and clinical inactivity of her acromegaly experienced a recurrence of active disease. Endocrine evaluation led to the discovery of hypopituitarism in association with hypersecretion of growth hormone. Patients with acromegaly and an episode of pituitary apoplexy with resultant inactive disease require long-term follow-up for the possibility of recurrence of active acromegaly.
Werner PL, Shah JH, Kukreja SC, Miller SM, Williams GA. Recurrence of Acromegaly After Pituitary Apoplexy. JAMA. 1982;247(20):2816-2818. doi:10.1001/jama.1982.03320450050035