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Article
September 23, 1988

Assessment of Laboratory Quality in Urine Drug TestingA Proficiency Testing Pilot Study

Author Affiliations

From the Research Triangle Institute, Research Triangle Park, NC (Mr Davis); National Institute on Drug Abuse, Rockville, Md (Dr Hawks); and Medical College of Virginia, Virginia Commonwealth University, Richmond (Dr Blanke).

From the Research Triangle Institute, Research Triangle Park, NC (Mr Davis); National Institute on Drug Abuse, Rockville, Md (Dr Hawks); and Medical College of Virginia, Virginia Commonwealth University, Richmond (Dr Blanke).

JAMA. 1988;260(12):1749-1754. doi:10.1001/jama.1988.03410120095034
Abstract

As part of a program to develop accreditation guidelines for urine drug testing laboratories, a pilot study for proficiency testing was conducted. Fifty civilian, commercial laboratories were included on a voluntary basis. Drug-free urine specimens were collected and either fortified with commonly abused drugs at concentrations comparable to casual use or submitted unfortified to participating laboratories as blanks. Samples were submitted on both an open and blind basis to the laboratories. Laboratory performance on open proficiency testing was comparable with that reported in existing proficiency testing programs. Blind proficiency testing produced less accurate results in terms of apparent false-negatives, but significant difficulties were evident in carrying out blind testing and in comparing its results with those of open testing. Specific problems have been identified to guide future programs.

(JAMA 1988;260:1749-1754)

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