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March 20, 1981

Vitamin B12 Deficiency and Early Rise in Mean Corpuscular Volume

Author Affiliations

From the Hematology Research Laboratory, Veterans Administration Medical Center, Albany, NY, and the Department of Medicine, Albany Medical College.

JAMA. 1981;245(11):1144-1146. doi:10.1001/jama.1981.03310360036019

An increase in the mean corpuscular volume (MCV), while not diagnostic of vitamin B12 or folate deficiency, is a valuable, readily available screening test. I discuss six instances where an increased MCV was recorded months prior to diagnosis and could, if noted, have led to an earlier diagnosis.

(JAMA 1981;245:1144-1146)