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April 17, 1981

Transatlantic trip of marrow donor failed to help infant

JAMA. 1981;245(15):1514-1515. doi:10.1001/jama.1981.03310400006002

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Bone marrow transplantation still offers a fighting chance to children with the autosomal recessive form of osteopetrosis (marble bone disease). Sadly, the first child to receive a transplant from an unrelated donor died recently at Rainbow Babies' and Children's Hospital in Cleveland. But his death occurred before engraftment had had a chance to take place and was not donor related, says Peter F. Coccia, MD, acting director of pediatric hematology-oncology at the hospital.

Coccia, who is also associate professor of pediatrics at Case Western Reserve University School of Medicine, Cleveland, told JAMA MEDICAL NEWS that a high fever developed in the 10-month-old boy five days after he received an infusion of processed bone marrow from an adult female donor who made a highly publicized trip to Cleveland from London for the transplant. The child was given antibiotics, which did not help his condition. Presumably, the cause of death was an