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Bone marrow transplantation still offers a fighting chance to children with the autosomal recessive form of osteopetrosis (marble bone disease). Sadly, the first child to receive a transplant from an unrelated donor died recently at Rainbow Babies' and Children's Hospital in Cleveland. But his death occurred before engraftment had had a chance to take place and was not donor related, says Peter F. Coccia, MD, acting director of pediatric hematology-oncology at the hospital.
Coccia, who is also associate professor of pediatrics at Case Western Reserve University School of Medicine, Cleveland, told JAMA MEDICAL NEWS that a high fever developed in the 10-month-old boy five days after he received an infusion of processed bone marrow from an adult female donor who made a highly publicized trip to Cleveland from London for the transplant. The child was given antibiotics, which did not help his condition. Presumably, the cause of death was an
González ER. Transatlantic trip of marrow donor failed to help infant. JAMA. 1981;245(15):1514–1515. doi:10.1001/jama.1981.03310400006002