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June 15, 1994

The Effect of Transplant Center Volume on Cardiac Transplant OutcomeA Report of the United Network for Organ Sharing Scientific Registry

Author Affiliations

From the Research Department of the United Network for Organ Sharing, Richmond, Va (Drs Hosenpud, Breen, Edwards, Daily, and Hunsicker); the Department of Medicine, Oregon Health Sciences University, Portland (Dr Hosenpud); and the Department of Medicine, University of Iowa Medical Center, Iowa City (Dr Hunsicker).

JAMA. 1994;271(23):1844-1849. doi:10.1001/jama.1994.03510470048033

Objective.  —The number of cardiac transplant programs continues to increase despite no increase in the number of hearts available for transplantation. As a result, the majority of heart transplant centers perform extremely small numbers of transplant operations annually. To determine the effect of small transplantation volume on transplant outcome, the following study was performed.

Design.  —Using the Scientific Registry of the United Network for Organ Sharing, all cardiac transplant procedures from October 1987 through December 1991 were analyzed to determine whether center volumes affected cardiac transplant outcome. Patient survival rates for each center were determined, and the survival rates were modeled for the following patient variables: first transplantation or retransplantation, patient condition at the time of transplantation, patient underlying cardiac disease (congenital vs all others), and time.

Setting.  —All cardiac transplant centers in the United States were included in the analysis.

Patients.  —All patients undergoing cardiac transplantation in the United States from October 1987 through December 1991 were included in the analysis.

Main Outcome Measure.  —The primary end point in this analysis was mortality.

Results.  —Throughout the entire study, of the 150 cardiac transplant centers, 35.3% of the centers were performing fewer than five cardiac transplantations per year, 53.3% were performing fewer than nine transplantations per year, and 61.3% were performing fewer than 12 transplantations per year, the minimum required for Medicare payment eligibility. Using the modeled survival rates, the risk of mortality decreased to a basal level in those centers performing between eight and 10 transplant operations per year. In centers performing fewer than nine transplantations, mortality increased sharply and exponentially. Dividing centers into those that performed nine or more transplantations per year (70 centers) and fewer than nine transplantations per year (80 centers), the increased risk of mortality at 1 month and 12 months was 40.3% and 33.1%, respectively, in centers performing fewer than nine cardiac transplantations per year (P<.001). Once the threshold of nine transplant procedures was met, those centers that were eligible for Medicare payment did not have significantly better survival than those centers not eligible for Medicare coverage.

Conclusions.  —These data demonstrate that the risk of mortality at early and intermediate time points is substantially higher in low-volume cardiac transplant centers, which make up more than half of the centers performing cardiac transplantation in the United States.(JAMA. 1994;271:1844-1849)