[Skip to Content]
[Skip to Content Landing]
Article
June 26, 1981

Selection of Patients With Chronic Obstructive Pulmonary Disease for Long-term Oxygen Therapy

Author Affiliations

From the Department of Medicine, Scripps Clinic and Research Foundation, and the Department of Medicine, University of California, San Diego (Dr Timms); the Division of Pulmonary Medicine, Henry Ford Hospital, Detroit, and the Department of Medicine, University of Michigan, Ann Arbor (Dr Kvale); the Division of Pulmonary Medicine, Department of Medicine, University of Manitoba, Winnipeg (Dr Anthonisen); the Department of Medicine, University of Southern California, Los Angeles (Dr Boylen); Division of Pulmonary Diseases, Northwestern University Medical School, Chicago (Dr Cugell); Pulmonary Division, Department of Medicine, University of Colorado, Denver (Dr Petty); and the Department of Biostatistics, University of Michigan, Ann Arbor (Dr Williams).

JAMA. 1981;245(24):2514-2515. doi:10.1001/jama.1981.03310490032020
Abstract

The Nocturnal Oxygen Therapy Trial, a study of oxygen therapy in patients with chronic obstructive pulmonary disease, has combined the experience of six centers concerning the selection of patients for oxygen treatment. Forty-five percent of hypoxic patients initially selected for the study improved enough during the one month of outpatient observation to allow suspension of plans to treat them with oxygen. Therefore, long-term oxygen therapy plans should only be made without a month of careful observation. Resting Pao2 values less than 40 mm Hg suggest instability or that chronic obstructive pulmonary disease is not the only cause of the hypoxemia. Nasal prong oxygen flow of 1 to 3 L/min reversed hypoxemia in 95% of stable patients with chronic obstructive pulmonary disease.

(JAMA 1981;245:2514-2515)

×