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We thank Drs Thase and Perel in suggesting that we add imipramine and other tricyclic antidepressants to the growing list of newer antiarrhythmic drugs. In our review, the intent was not to discuss all new antiarrhythmic drugs. Rather, it was to present, in a brief compass, the salient features of those compounds that have been studied somewhat extensively. For this reason, we did not describe the properties or the role of the tricyclic compounds pirmenol hydrochloride, cibenzoline, sotalol, clofilium phosphate, propafenone, or moricizine. Undoubtedly, ongoing studies will clarify the relative merits and roles of these compounds in the control of disorders of cardiac rhythm.
Nademanee K, Singh BN. Antiarrhythmic Effects of Tricyclic Antidepressants-Reply. JAMA. 1982;248(4):429. doi:10.1001/jama.1982.03330040023023