Acute lymphoblastic leukemia developed in a girl with Wilson's disease after 37 months of high-dose penicillamine therapy. We postulate that penicillamine-induced alterations in host immunity may cause a predisposition to certain malignancies, similar to that which occurs in other acquired or inherited immunodeficiency states.
Gilman PA, Holtzman NA. Acute Lymphoblastic Leukemia in a Patient Receiving Penicillamine for Wilson's Disease. JAMA. 1982;248(4):467–468. doi:10.1001/jama.1982.03330040055032